|
KMID : 0605620120190040193
|
|
Journal of Korean Society of Biological Psychiatry
2012 Volume.19 No. 4 p.193 ~ p.198
|
|
|
Relationship between Serum Inflammatory Marker and Psychotic Symptoms in Inpatients with Schizophrenia or Schizoaffective Disorder
|
|
Kim Kye-Hwan
Lee Koun-Seok
Kim Su-Jin
Lee Eun-Kyu
Song Yul-Mai
Park Jin-Young
|
|
|
Abstract
|
|
|
Objectives: Despite the growing research interest in the role of immunological markers in schizophrenia, a few studies, with conflicting results, have focused on the association between high sensitivity C-reactive protein (hs-CRP) levels and clinical characteristics in schizophrenia. The aim of the present study was to examine the association of serum hs-CRP with psychopathology in schizophrenia.
Methods: Fifty-five inpatients with schizophrenia or schizoaffective disorder were enrolled. Serum levels of hs-CRP were measured, and each patient was assessed with the Korean version of the Positive and Negative Syndrome Scale (PANSS).
Results: In correlation analysis of hs-CRP with PANSS subscales, positive subscale score has significant positive correlation (r = 0.271, p = 0.046). In independent t-test analysis, subjects with hs-CRP > 0.3 mg/dL (elevated CRP group, n = 43) had significantly higher PANSS positive subscale score (t = -3.273, df = 24.107, p = 0.003) than those with hs-CRP ≤ 0.3 mg/dL (normal CRP group, n = 12).
Conclusions: Elevated serum levels of high sensitivity C-reactive protein in schizophrenia are associated with the severity of psychotic symptoms.
|
|
|
KEYWORD
|
|
|
C-reactive protein, Inflammatory marker, Schizophrenia, Positive symptoms
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|
|